Quinoline, 4,7-dichloro-2-(trifluoromethyl)-

Quinoline, 4,7-dichloro-2-(trifluoromethyl)- - Names and Identifiers

Name	4,7-dichloro-2-(trifluoromethyl)quinoline
Synonyms	4,7-Dichloro-2-trifluoromethylquinoline 4,7-dichloro-2-(trifluoromethyl)quinoline 4,7-DICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE Quinoline, 4,7-dichloro-2-(trifluoromethyl)-
CAS	702640-95-7

Quinoline, 4,7-dichloro-2-(trifluoromethyl)- - Physico-chemical Properties

Molecular Formula	C10H4Cl2F3N
Molar Mass	266.05
Storage Condition	2-8℃

Quinoline, 4,7-dichloro-2-(trifluoromethyl)- - Introduction

4,7-dichloro-2-(trifluoromethyl)quinoline is an organic compound with the formula C11H5Cl2F3N. The following is a description of the properties, uses, preparation and safety information of this compound.

Nature:
-Appearance: 4,7-dichloro-2-(trifluoromethyl)quinoline is a colorless to pale yellow crystal or crystalline solid.
-Solubility: Soluble in organic solvents such as chloroform, dimethylformamide and dichloromethane, but low solubility in water.
-Melting point: about 90-95 ℃.
-Stability: relatively stable at room temperature, but avoid contact with strong oxidants or strong acids.

Use:
-Chemical reagent: 4,7-dichloro-2-(trifluoromethyl)quinoline is often used as a reagent in organic synthesis, such as in the synthesis of fluoroborate.
-Drug research: The compound also has certain applications in drug research, such as as an organic synthesis intermediate for drug structure.

Preparation Method:
The synthesis of 4,7-dichloro-2-(trifluoromethyl)quinoline usually proceeds via the following reaction pathways:
1. In the presence of 2,3-dichloroquinoline, acetyl fluoride or hydrogen fluoride in a gaseous state is reacted with 1,2-dichlorobenzene to obtain 2-fluoro-1, 2-dichlorobenzene.
2.2-Fluoro -1,2-dichlorobenzene is reacted with cyanobromide magnesium to obtain 2-cyano -1,2-dichlorobenzene.
3. Under the catalysis of aluminum chloride, 2-cyano -1,2-dichlorobenzene is rearranged into 2-cyano -1,2,3-trichlorobenzene according to the Amadori rearrangement reaction.
4. Finally, 2-cyano-1, 2,3-trichlorobenzene was reacted with trifluoroformate to give 4,7-dichloro-2-(trifluoromethyl)quinoline.

Safety Information:
- 4,7-dichloro-2-(trifluoromethyl)quinoline should be operated in a well-ventilated environment to avoid inhaling dust or gas.
-Wear appropriate personal protective equipment, such as lab gloves and goggles, during use or handling.
-Due to the toxicity and irritation of this compound, direct contact with skin and eyes should be avoided.
-During storage and handling, it should be separated from flammable and easily oxidized items.

When using or handling this compound, be sure to follow specific laboratory safety procedures and consult relevant professionals for advice.

Last Update：2024-04-09 21:04:16